Long-term adaptation of the influenza A virus by escaping cytotoxic T-cell recognition
Identifieur interne : 000024 ( 1968/Analysis ); précédent : 000023; suivant : 000025Long-term adaptation of the influenza A virus by escaping cytotoxic T-cell recognition
Auteurs : Rutger G. Woolthuis [Pays-Bas] ; Christiaan H. Van Dorp [Pays-Bas] ; Can Ke Mir [Pays-Bas] ; Rob J. De Boer [Pays-Bas] ; Michiel Van Boven [Pays-Bas]Source :
- Scientific Reports [ 2045-2322 ] ; 2016.
Abstract
The evolutionary adaptation of the influenza A virus (IAV) to human antibodies is well characterised. Much less is known about the long-term evolution of cytotoxic T lymphocyte (CTL) epitopes, which are important antigens for clearance of infection. We construct an antigenic map of IAVs of all human subtypes using a compendium of 142 confirmed CTL epitopes, and show that IAV evolved gradually in the period 1932–2015, with infrequent antigenic jumps in the H3N2 subtype. Intriguingly, the number of CTL epitopes per virus decreases with more than one epitope per three years in the H3N2 subtype (from 84 epitopes per virus in 1968 to 64 in 2015), mostly attributed to the loss of HLA-B epitopes. We confirm these observations with epitope predictions. Our findings indicate that selection pressures imposed by CTL immunity shape the long-term evolution of IAV.
Url:
DOI: 10.1038/srep33334
PubMed: 27629812
PubMed Central: 5024124
Affiliations:
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PMC:5024124Le document en format XML
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Rambaut</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Goldfield, M" uniqKey="Goldfield M">M. Goldfield</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sidney, J" uniqKey="Sidney J">J. Sidney</name></author><author><name sortKey="Peters, B" uniqKey="Peters B">B. Peters</name></author><author><name sortKey="Frahm, N" uniqKey="Frahm N">N. Frahm</name></author><author><name sortKey="Brander, C" uniqKey="Brander C">C. Brander</name></author><author><name sortKey="Sette, A" uniqKey="Sette A">A. Sette</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mukherjee, S" uniqKey="Mukherjee S">S. Mukherjee</name></author><author><name sortKey="Chandra, N" uniqKey="Chandra N">N. Chandra</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sievers, F" uniqKey="Sievers F">F. Sievers</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Pays-Bas</li></country></list><tree><country name="Pays-Bas"><noRegion><name sortKey="Woolthuis, Rutger G" sort="Woolthuis, Rutger G" uniqKey="Woolthuis R" first="Rutger G." last="Woolthuis">Rutger G. Woolthuis</name></noRegion><name sortKey="De Boer, Rob J" sort="De Boer, Rob J" uniqKey="De Boer R" first="Rob J." last="De Boer">Rob J. De Boer</name><name sortKey="Ke Mir, Can" sort="Ke Mir, Can" uniqKey="Ke Mir C" first="Can" last="Ke Mir">Can Ke Mir</name><name sortKey="Van Boven, Michiel" sort="Van Boven, Michiel" uniqKey="Van Boven M" first="Michiel" last="Van Boven">Michiel Van Boven</name><name sortKey="Van Dorp, Christiaan H" sort="Van Dorp, Christiaan H" uniqKey="Van Dorp C" first="Christiaan H." last="Van Dorp">Christiaan H. Van Dorp</name><name sortKey="Van Dorp, Christiaan H" sort="Van Dorp, Christiaan H" uniqKey="Van Dorp C" first="Christiaan H." last="Van Dorp">Christiaan H. Van Dorp</name><name sortKey="Woolthuis, Rutger G" sort="Woolthuis, Rutger G" uniqKey="Woolthuis R" first="Rutger G." last="Woolthuis">Rutger G. Woolthuis</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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